Ferdowsi University of Mashhad
1. Network Analysis of Differential Gene Expression to Identify Hub Genes in Ovarian Cancer

Akram Siavoshi; Mahdieh Taghizadeh; Elahe Dookhe; Mehran Piran; Mahsa Saliani; Shahla Mohammad Ganji

Volume 12, Issue 1 , Summer and Autumn 2020, Pages 1-9


       Epithelial ovarian cancer (EOC), as a challenging disease among women with poor prognosis and unclear molecular pathogenesis, each year is responsible for 140000 deaths globally. Recent progress in the field revealed the importance of proteins as key players of different biological ...  Read More

2. Identification and Functional Profiling of Differentially Expressed Extracellular Vesicle-free MicroRNAs for Efficient Prostate Cancer Diagnosis

Mina Jahandideh; Ebrahim Barzegari

Volume 12, Issue 1 , Summer and Autumn 2020, Pages 10-21


       MicroRNAs are interesting as cancer diagnostic and prognostic biomarkers because of their unique tissue expression profiles, higher stability in the blood in comparison to mRNAs, and the possibility for reliable quantification. In the case of prostate cancer (PCa), it is currently ...  Read More

3. Identification of Breast Cancer Associated Putative Functional Single Nucleotide Polymorphisms in the Iranian Population through In Silico Analyses

Vida Nadafi Sichani; Seyed Alireza Emami; Morteza Bitaraf Sani; Mohammadreza Nassiri; Vinod Gopalan

Volume 12, Issue 1 , Summer and Autumn 2020, Pages 22-32


       Previous studies have found several distinct alleles at both levels of transcriptional activity and protein-DNA binding manners in breast cancer patients vs. healthy individuals through multi-step experimental approaches. This study presents a computational-based model to investigate ...  Read More

4. Element Accumulations in Liver and Kidney Tissues of Some Bony Fish Species in the Southwest Caspian Sea

Masoud Sattari; Mehdi Bibak; Shima Bakhshalizadeh; Mohammad Forouhar Vajargah

Volume 12, Issue 1 , Summer and Autumn 2020, Pages 33-40


       The Caspian Sea is the largest inland body of water in the world and so has both common characteristics of seas and lakes with over 153 fish species which inhabit the sea and its basin. However, little is known about the trace element (TE) contaminations (TECs) in its tissues. In ...  Read More

5. Association of TOMM40, CHAT and SORL1 Polymorphisms with the Alzheimer’s Disease in the Turkish-speaking Azeri population in Northwest of Iran

Nazanin Mardokh Rohani; Mohammad Khalaj-Kondari; Majid Khodayi-Shahrak; Mahnaz Talebi; Mohammad Ali Hoseinpur Feizi

Volume 12, Issue 1 , Summer and Autumn 2020, Pages 41-48


       Recent genome-wide association studies have introduced several genetic variants which contribute to the late-onset Alzheimer's disease (LOAD). Polymorphisms of CHAT, TOMM40, and SORL1 genes have been reported to be associated with the LOAD phenotype. This study was endeavored to evaluate ...  Read More