Ferdowsi University of Mashhad
LncRNA HOXD-AS1 Is Upregulated in Ovarian Cancer

Seyedeh Nahid Fotuhi; Mohammad Khalaj-Kondori; Hadis Karimi

Volume 12, Issue 2 , March 2021, Pages 49-55


       Patients with ovarian cancer are mostly diagnosed at advanced stages which leads to poor prognosis and high mortality rate. Deregulation of lncRNA HOXD-AS1 expression associates with cancer development and metastasis. However, the expression level of this lncRNA in ovarian cancer ...  Read More

Cloning and Expression of a Fusion Protein Containing Highly Epitopic Regions of Clostridium perfringens Epsilon Toxin and Clostridium novyi Alpha Toxin

Mohsen Mehrvarz; Mohsen Fathi Najafi; Taghi Zahraei Salehi; Behjat Majidi

Volume 12, Issue 2 , March 2021, Pages 56-64


       Clostridium perfringens and novyi species are two important toxin-producing pathogens which pose a risk to the livestock health. Epsilon and alpha toxins are major toxins of these two pathogens, respectively. Advances in current vaccine industrialization lead to the utilization ...  Read More

Signal Transduction of Unique RAS Family Member towards Cell Survival

Saeideh Nakhaei-Rad

Volume 12, Issue 2 , March 2021, Pages 65-73


       Small GTPases of RAS act as central regulators of intracellular signal transduction and translate external stimuli to the various cellular responses. Embryonic stem cell expressed RAS (ERAS) is a member of the RAS family that is specifically expressed in undifferentiated mouse embryonic ...  Read More

Immunological Window of Myocardial Infarction

Azadeh Haghighitalab; Mahboubeh Kazemi Noughabi; Shima Minaee; Ahmad Amin; Ahmad Reza Bahrami

Volume 12, Issue 2 , March 2021, Pages 74-86


       Acute myocardial infarction (MI) describes as an irreversible death of heart muscle which is initiated by a shortage of myocardium oxygen supply and accompanies by a complex of pro- and anti-inflammatory events. During the last decades, innate and adaptive immune responses are considered ...  Read More

Comparative in silico Survey of Retinoic Acids as Putative Biomolecules Against VEGF Receptors: A Glycomics-based Approach

Ali Fallah; Esmaeil Samadian; Azadeh Mohammad-Hasani; Abasalt Hosseinzadeh Colagar

Volume 12, Issue 2 , March 2021, Pages 87-96


       In this study, putative interactions between all of the retinoic acid (RA) ligands (all-trans (At), 9-cis (9c), and 13-cis (13c)), and VEGF receptors (VEGFR-1, -2 and -3) were investigated. It was performed considering the glycosylation status of the receptors to achieve a more reliable ...  Read More

Identification of Bacterial Proteins in the Gut of Sunn pest, Eurygaster integriceps

Mohammad Saadati; Mahmoud Toorchi

Volume 12, Issue 2 , March 2021, Pages 97-103


       Proteomics is a powerful tool to identify effective proteins in the biochemical reactions of the insect body. Many proteins were reported in the gut lumen and tissues which are essential to complete the physiological role of the alimentary canal of Sunn pest. The gut microbiome of ...  Read More

Identification of Suitable Housekeeping Genes for Quantitative Gene Expression Analysis During Retinoic Acid-induced Differentiation of Embryonal Carcinoma NCCIT Cells

Sara Soltanian; Mahboubeh Sheikhbahaei

Volume 12, Issue 2 , March 2021, Pages 104-110


       Real-time quantitative PCR (qRT-PCR) is often used as an effective experimental method for analyzing gene expression. In this method, normalization of target gene expression levels must be performed using housekeeping genes (HKGs). HKGs are used to compensate for difference between ...  Read More