Ferdowsi University of Mashhad

1. Exploring the Anticancer Efficacy of Mixture of Local Probiotics on MDA-MB-231 and MCF-7 Breast Cell Lines

Mohadese Abdoli; Parisa Fathi Rezaei; Kamran Mansouri

Articles in Press, Accepted Manuscript, Available Online from 27 April 2021

http://dx.doi.org/10.22067/jcmr.2021.68651.1001

Abstract
  The aim of this study was to investigate the cytotoxicity of probiotic mixture on breast cancer cell lines. A mixture of local probiotic bacteria was cultured and the supernatant was lyophilized for performing additional experiments. The antioxidant activity, total phenol content (TPC) and fatty acid ...  Read More

2. Bioassay and Molecular Screening of Nitrate Reductase Enzymes in halophilic bacteria

Saeedeh Sibevieh; Ensieh Salehghamari; Mohammad Ali Amoozegar; Mohammad Reza Zolfaghari; Mohammad Soleimani; Zohre Nasrollahzadeh; Sara Eftekhari Yazdi

Articles in Press, Accepted Manuscript, Available Online from 05 May 2021

http://dx.doi.org/10.22067/jcmr.2021.64301.0

Abstract
  With the increased usage of nitrate fertilizers, as it is a stable ion with high solubility in water, its removal is a challenge for human health. Several physicochemical methods have been examined for nitrate removal of water, but nowadays the biological treatment of it from soil and water are widely ...  Read More

3. Royal Jelly Decreases MMP-9 Expression and Induces Apoptosis in Human Bladder Cancer 5637 Cells

Narges Fazili; Zahra-Soheila Soheili; Saeid Malekzadeh-Shafaroudi; Shahram Samiei; Nasrin Moshtaghi; Abouzar Bagheri

Articles in Press, Accepted Manuscript, Available Online from 09 July 2021

http://dx.doi.org/10.22067/jcmr.2021.68523.1000

Abstract
  Royal jelly (RJ) from queen honeybee larva as a traditional medicine agent has a variety of pharmacological benefits. In the present study, the effect of Royal jelly was investigated on the urinary bladder cancer cell line (HTB-9 5637). To determine the cell viability in different concentrations ...  Read More

4. Comparative Analysis of Commercial CCL21 and CCL21/IL1β Recombinant Protein by In Silico Tools

Ahdiyeh Shahtaghi; Ali Alam Shahnabadi; Kamelia Kohannezhad; Neda Amini; Maria Beihaghi

Articles in Press, Accepted Manuscript, Available Online from 22 July 2021

http://dx.doi.org/10.22067/jcmr.2021.69999.1005

Abstract
  One of the newest diagnostic methods and treatment of cancer is to design new drugs. It is now possible to design a drug with desired properties in theory and evaluate its therapeutic effects through bioinformatics tools. Among the studied drugs; those based on cytokine genes, which increase the body's ...  Read More

5. Vitamin C Loaded Albumin Nanoparticles Treatment and Its Effect on Collagen I and III and mir-133 Genes Expression

Hamid Reza Shojania; Madjid Momeni Moghaddam; Seyed Ebrahim Hossini

Articles in Press, Accepted Manuscript, Available Online from 06 August 2021

http://dx.doi.org/10.22067/jcmr.2021.71443.1011

Abstract
  Wound healing is a complex biological process in which many molecules, including microRNA molecules, play an important role in its regulation. It is well established that reducing mir-155 expression can accelerate wound healing. In this study, the effect of using nanoparticle loaded by vitamin C in wound ...  Read More

6. VEGF-C and p53 Gene Expression in the Normal and Neoplastic Mammary Gland of Canines: A Pilot Study

Mohammadreza Nassiri; Azadeh Safarchi; Masoume Vakili-Azghandi; Vinod Gopalan; Mohammad Doosti; Shahrokh Ghovvati; Ahmad Reza Movassaghi

Articles in Press, Accepted Manuscript, Available Online from 14 August 2021

http://dx.doi.org/10.22067/jcmr.2021.71259.1008

Abstract
  p53 is a tumor suppressor protein that plays an essential role in controlling the cell and vascular endothelial growth factor (VEGF) is one of the most strong and specific angiogenic factors. The main objective of this study was to evaluate the impact of p53 and VEGF-C gene expression in the neoplastic ...  Read More

7. Characterization of lytic bacteriophages infecting antibiotic-resistant Escherichia coli strains isolated from urinary tract infections in the north-west of Iran

Raheleh Majdani

Articles in Press, Accepted Manuscript, Available Online from 15 August 2021

http://dx.doi.org/10.22067/jcmr.2021.70313.1006

Abstract
  Urinary tract infection, as one of the most prevalent bacterial infections, affecting millions of people yearly worldwide. Due to control of increasingly antibiotic resistant infections, it is needed to introduce the alternative approaches such as phage therapy. In this study, isolation, purification ...  Read More

8. A Multi-Faceted Approach for Prediction of Genome Safe Harbor Loci in the Chicken Genome

Nima Dehdilani; Mohsen Fathi Najafi; Hesam Dehghani

Articles in Press, Accepted Manuscript, Available Online from 23 August 2021

http://dx.doi.org/10.22067/jcmr.2021.71604.1015

Abstract
  To achieve a reliable and persistent expression over time, the transgene should be precisely integrated into the genome safe harbor (GSH) loci. Little attention has been paid to find the safe harbor loci of the chicken (Gallus gallus domesticus) genome. Identification and characterization of GSH loci ...  Read More

9. Effect of glutamine stability on the long-term culture and line establishment of chicken primordial germ cells

Sara Yousefi taemeh; Jalil Mehrzad; Hesam Dehghani

Articles in Press, Accepted Manuscript, Available Online from 14 September 2021

http://dx.doi.org/10.22067/jcmr.2021.71863.1017

Abstract
  Primordial germ cells (PGCs) are precursors for mature gametes, which transmit genetic information to the next generation. Due to the importance of PGCs in many fields including developmental biology, genome editing, transgenesis, and conservation of avian genetic resources, a lot of research has focused ...  Read More

10. Understanding the Effect of Natural Products on Breast Cancer via P53-MDM 2 Signal Pathway

Zahra Ghavidel; Madjid Momeni Moghaddam; Toktam Hajar; Eisa Kohan

Articles in Press, Accepted Manuscript, Available Online from 14 September 2021

http://dx.doi.org/10.22067/jcmr.2021.71513.1012

Abstract
  The use of medicinal plants in the treatment of diseases has a long history dating back to the human presence on Earth. Cancer, has always been an incurable disease, and among the various cancers, breast cancer is one of the most important causes of death in women and imposes difficult conditions on ...  Read More

11. The Effect of Androgen Deprivation on the Expression of Connexin-43 mRNA in the Heart

Mahnaz Ghowsi; Nazli Khajehnasiri; Sajjad Sisakhtnezhad

Articles in Press, Accepted Manuscript, Available Online from 20 September 2021

http://dx.doi.org/10.22067/jcmr.2021.71395.1010

Abstract
  Connexin-43 (Cx-43) plays axial roles in the propagation of action potentials and contractile coupling in heart. Down-regulation of Cx-43 in heart is associated with arrhythmia, dilated cardiomyopathy and heart failure. To date, no studies have examined the effects of androgen deprivation therapy (ADT)-induced ...  Read More