Document Type : Research Articles
Authors
1 Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad
2 Department of Animal Science-Faculty of Agriculture-Ferdowsi University of Mashhad
Abstract
Rotavirus infections impose a significant global health burden, particularly affecting infants and young children and causing severe gastroenteritis . To combat this viral pathogen , there is a growing interest in exploring the therapeutic potential of lactoferrins derived from different farm animal milk as antiviral agents. This study employed molecular simulation techniques to investigate the intricate binding mechanisms between different animal milk lactoferrins and rotavirus, providing insights into their molecular interactions . These animals were including cow , sheep , camel , goat , horse , buffalo in addition to human . Molecular dynamics simulation techniques were employed using Gromacs software to simulate the interaction between animal milk lactoferrins and rotavirus. Precise computational models and simulations were conducted to investigate the binding mechanisms and identify critical amino acid residues involved.Our findings indicate that cow lactoferrin exhibits superior interaction with rotavirus compared to other lactoferrin sources . We identified specific binding sites and crucial amino acid residues responsible for these interactions . These results provide insights into the molecular determinants governing the binding affinity and specificity of lactoferrins towards rotavirus. This study offers valuable insights for the design of targeted antiviral strategies against rotavirus infections . Animal milk lactoferrins , particularly cow lactoferrin , demonstrated a promising potential as an antiviral agent against retroviruses. These findings enhanced our understanding of the molecular mechanisms underlying lactoferrin - mediated antiviral activity, paving the way for future experimental and clinical investigations in this field and supporting the development of efficient antiviral therapeutics against rotavirus.
Keywords
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