Ferdowsi University of Mashhad
The Effect of Cartilage and Bacteria-derived Glycoproteins as a Biological Dressing on Wound Healing

Fatemeh Naseri; Gholamreza Hashemitabar; Nasser Mahdavi Shahri; Hossein Nourani; Amin Tavassoli

Volume 13, Issue 2 , April 2022, Pages 98-107


                Immediate intervention with minimal side effects is the most significant factor in the enhancement of wound healing. However, a majority of drugs used for this purpose are chemical-based containing various compounds, such ...  Read More

In silico Study to Identification of Potential SARS-CoV-2 Main Protease Inhibitors: Virtual Drug Screening and Molecular Docking with AutoDock Vina and Molegro Virtual Docker

Mohammad Amin Manavi

Volume 13, Issue 2 , April 2022, Pages 108-112


  Coronavirus disease 2019 (COVID-19) has emerged in Wuhan, China, and because of fast transmission, it has led to its extensive prevalence in almost all countries, which has made it a global crisis. Drug repurposing is considered a fast way to discover new applications of the current drugs. This study ...  Read More

Production and Purification of Recombinant B Subunit of Vibrio cholerae Toxin in Escherichia coli

Ali Khastar; Majid Jamshidain-Mojaver; Hamidreza Farzin; Masoumeh Jomhori Baloch; Iman Salamatian; Kaveh Akbarzadeh-Sherbaf

Volume 13, Issue 2 , April 2022, Pages 113-120


  Cholera toxin B subunit (CTB) is a non-toxic and immunostimulatory component of Vibrio cholera toxin. CTB is one of the most studied protein compounds for adjuvant design. This study aimed to produce and purify recombinant CTB (rCTB) by pET-22a plasmid in Escherichia coli BL21(DE) strain, focusing on ...  Read More

Highly Association of HLA-A*03/A*31 and HLA-A*24/A*31 Haplotypes with Multiple Sclerosis

Seyed Javad Rajaei; Mostafa Shakhsi-Niaei; Masoud Etemadifar

Volume 13, Issue 2 , April 2022, Pages 121-128


                Multiple sclerosis (MS) is an autoimmune disease of the central nervous system with unknown etiology. Recent evidences suggest the HLA contribution to Multiple sclerosis (MS) pathogenicity as they may present neuropeptides ...  Read More

Alternative Splicing Novel lncRNAs and Their Target Genes in Ovine Skeletal Muscles

Saad Badday Betti; Mojtaba Tahmoorespur; Ali Javadmanesh

Volume 13, Issue 2 , April 2022, Pages 129-136


  Long non-coding RNAs (lncRNAs) compose a plentiful category of transcripts that have gained increasing importance because of their roles in different biological processes. Although the function of most lncRNAs remains unclear. They are implicated in epigenetic regulation of gene expression, including ...  Read More

LncRNAs as Regulators of the STAT3 Signaling Pathway in Cancer

Narges ZadehRashki; Zahra Shahmohammadi; ZahraSadat Damrodi; Sohrab Boozarpour; Arezou Negahdari; Nazanin Mansour Moshtaghi; Mehdi Vakilinejad; Shaaban Ghalandarayeshi

Volume 13, Issue 2 , April 2022, Pages 137-150


  Cancer is a disorder of growth control and cell differentiation caused by the abnormal expression of multiple genes. Long non-coding RNAs (lncRNAs) are critical regulators of numerous biological processes, especially in the development of diseases. Abnormal expression of some lncRNAs causes disease, ...  Read More

Appropriate Reference Gene for the Gene Expression Analysis in U87 Glioblastoma Cell Line

Mina Lashkarboloki; Amin Jahanbakhshi; Seyed Javad Mowla; Bahram Mohammad Soltani

Volume 13, Issue 2 , April 2022, Pages 151-155


  Cancer is one of the most challenging diseases in the world. It is widely accepted that knowing the molecular aspects of diseases, including cancers, helps to develop methods for their therapy and diagnosis. Long non-coding RNAs (lncRANs) are a novel category of regulatory genes known to be involved ...  Read More