Ferdowsi University of Mashhad

Document Type : Research Articles


1 Department of biological sciences. North Tehran Branch Islamic Azad University , Tehran, Iran.

2 Kharazmi university

3 ,Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran .

4 Department of Radiology, PhD of Molecular medicine, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA.

5 Urologist, Department of Urology, Zahedan University of Medical Sciences, Zahedan-Iran.



Prostate cancer is the second most common malignancy worldwide and is the fifth leading cause of death in men. It is the second most common cancer among urinary tract cancers in Iranian men. The purpose of this study was to evaluate the association of rs10090154 which is located on 8q24 locus and rs1691053 on chromosome 5p15.31 with prostate adenocarcinoma, PSA and use them as screening factors if it is associated with prostate cancer.

In this case-control study, 79 patients with prostate adenocarcinoma with an age range of 48 to 86 years and 98 BPH patients with an age range of 47 to 81 years participated. Also, Tetra-primer ARMS-PCR (Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction) method was used to determine the genotype of each participant.

In this study, no significant difference in genotypic distribution between prostate adenocarcinoma and control groups was observed in rs10090154 (P-value= 0.608) and rs1691053 (P-value = 0.102) polymorphisms. Also, in the study of additive genetics model of rs10090154 polymorphism based on placing TT genotype as reference genotype CC genotype with P-value = 1 and OR{95%CI}= 0.750,{0 .039- 14.576} and CT genotype with P-value= 0.324 and OR{95%CI}= 0.577,{0 .191- 1.739} are not associated with additive genetics model. As well, in rs1691053 based on CC as a reference CT genotype with P-value =0.176 and OR{95%CI}= 0.196,{0.022-1.793} and TT genotype with P-value =0.464, OR{95%CI}= 0.125, {0 .005- 3.225} are not associated with additive genetics model.

the results of this study indicate that rs10090154 and rs1691053 are not associated with prostate cancer in Iranian population.