TY - JOUR ID - 43496 TI - Association Study of rs10090154 and rs1691053 With Predisposition to Prostate Adenocarcinoma in the Iranian Population JO - Journal of Cell and Molecular Research JA - JCMR LA - en SN - 2008-9147 AU - Dehquan Dehnavi, Roya AU - Angaji, Seyed Abdolhamid AU - Beikzadeh, Behnaz AU - Alibeik, Hengameh AU - Roudi, Raheleh AU - Narouie, Behzad AD - Department of Biological Sciences, North Tehran Branch Islamic Azad University, Tehran, Iran AD - Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran AD - Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran AD - Department of Radiology, Stanford University, Stanford, CA 94305, USA AD - Department of Urology, Zahedan University of Medical Sciences, Zahedan, Iran Y1 - 2023 PY - 2023 VL - 14 IS - 2 SP - 106 EP - 114 KW - prostate adenocarcinoma KW - Association KW - Tetra-primer ARMS-PCR KW - 8q24 KW - 5p15.31 DO - 10.22067/jcmr.2023.79067.1055 N2 - Prostate cancer is the second most prevalent malignancy in men and the fifth leading cause of death worldwide. It is the second most common urinary tract cancer among Iranian men. The aim of this study was to investigate the association between rs10090154, located on the 8q24 locus, and rs1691053 on chromosome 5p15.31, with prostate adenocarcinoma and PSA levels. This study also aimed to identify the potential of these genetic markers as screening factors. This case-control study included 79 patients with prostate adenocarcinoma aged between 48 to 86 years, as well as 98 patients with benign prostatic hyperplasia aged between 47 to 81 years. The Tetra-primer ARMS-PCR method was applied to determine the genotype of each participant. In this study, no significant differences in genotypic distribution between the prostate adenocarcinoma and control groups were discovered for rs10090154 (P-value = 0.608) and rs1691053 (P-value = 0.102) polymorphisms. Moreover, for the study of the additive genetics model of the rs10090154 polymorphism, with the TT genotype as the reference, the CC genotype with P-value = 1 and OR {95%CI} = 0.750, {0.039-14.576} and CT genotype with P-value = 0.324 and OR {95%CI} = 0.577, {0.191-1.739}, were not associated. Correspondingly, for rs1691053, with the CC genotype as the reference, the CT genotype with P-value = 0.176 and OR {95%CI}= 0.196, {0.022-1.793}, and the TT genotype with P-value= 0.464, OR{95%CI}= 0.125, {0.005-3.225}, were not associated. These findings suggest that rs10090154 and rs1691053 may not be associated with prostate cancer among Iranians. However, further research with larger sample sizes and investigation of various Iranian subpopulations are needed to confirm these results. UR - https://jcmr.um.ac.ir/article_43496.html L1 - https://jcmr.um.ac.ir/article_43496_bccd420174ab82c9159a5101ca733c94.pdf ER -