Ferdowsi University of Mashhad
1. Network Analysis of Differential Gene Expression to Identify Hub Genes in Ovarian Cancer

Akram Siavoshi; Mahdieh Taghizadeh; Elahe Dookhe; Mehran Piran; Mahsa Saliani; Shahla Mohammad Ganji

Volume 12, Issue 1 , Summer and Autumn 2020, , Pages 1-9

http://dx.doi.org/10.22067/jcmr.v12i1.85654

Abstract
       Epithelial ovarian cancer (EOC), as a challenging disease among women with poor prognosis and unclear molecular pathogenesis, each year is responsible for 140000 deaths globally. Recent progress in the field revealed the importance of proteins as key players of different biological ...  Read More

2. Identification and Functional Profiling of Differentially Expressed Extracellular Vesicle-free MicroRNAs for Efficient Prostate Cancer Diagnosis

Mina Jahandideh; Ebrahim Barzegari

Volume 12, Issue 1 , Summer and Autumn 2020, , Pages 10-21

http://dx.doi.org/10.22067/jcmr.v12i1.87155

Abstract
       MicroRNAs are interesting as cancer diagnostic and prognostic biomarkers because of their unique tissue expression profiles, higher stability in the blood in comparison to mRNAs, and the possibility for reliable quantification. In the case of prostate cancer (PCa), it is currently ...  Read More

3. Element Accumulations in Liver and Kidney Tissues of Some Bony Fish Species in the Southwest Caspian Sea

Masoud Sattari; Mehdi Bibak; Shima Bakhshalizadeh; Mohammad Forouhar Vajargah

Volume 12, Issue 1 , Summer and Autumn 2020, , Pages 33-40

http://dx.doi.org/10.22067/jcmr.v12i1.85975

Abstract
       The Caspian Sea is the largest inland body of water in the world and so has both common characteristics of seas and lakes with over 153 fish species which inhabit the sea and its basin. However, little is known about the trace element (TE) contaminations (TECs) in its tissues. In ...  Read More

4. Association of TOMM40, CHAT and SORL1 Polymorphisms with the Alzheimer’s Disease in the Turkish-speaking Azeri population in Northwest of Iran

Nazanin Mardokh Rohani; Mohammad Khalaj-Kondari; Majid Khodayi-Shahrak; Mahnaz Talebi; Mohammad Ali Hoseinpur Feizi

Volume 12, Issue 1 , Summer and Autumn 2020, , Pages 41-48

http://dx.doi.org/10.22067/jcmr.v12i1.87325

Abstract
       Recent genome-wide association studies have introduced several genetic variants which contribute to the late-onset Alzheimer's disease (LOAD). Polymorphisms of CHAT, TOMM40, and SORL1 genes have been reported to be associated with the LOAD phenotype. This study was endeavored to evaluate ...  Read More

5. Cost-effective Strategies for Depletion of Endogenous Extracellular Vesicles from Fetal Bovine Serum

Azadeh Haghighitalab; Maryam M. Matin; Fatemeh Khakrah; Ahmad Asoodeh; Ahmad Reza Bahrami

Volume 11, Issue 2 , Winter and Spring 2020, , Pages 42-54

http://dx.doi.org/10.22067/jcmr.v11i2.85209

Abstract
       Despite the prominent therapeutic potentials of stem cells, their use in cell therapy has been challenged with some unreproducible and inconsistent outcomes in addition to the risk of rejection and tumorigenesis. Gaining novel insights to the importance of the conditioned medium, ...  Read More

6. Production of Silver Nanoparticles by Marigold Extract

Zohreh Sohrabi Nezhad; Hassan Marashi; Nasrin Moshtaghi

Volume 11, Issue 2 , Winter and Spring 2020, , Pages 59-65

http://dx.doi.org/10.22067/jcmr.v11i2.84974

Abstract
       Silver nanoparticles are widely used in manufacturing of different products considering their unique physical and chemical properties. Also they have been noticed in medical diagnosis and treatment because of their antibacterial properties. Physical and chemical methods of producing ...  Read More

7. In silico Analysis of Determinant Factors in Microbial Protease Thermostability

Parisa Farrokh; Fatemeh Salimi

Volume 11, Issue 2 , Winter and Spring 2020, , Pages 66-81

http://dx.doi.org/10.22067/jcmr.v11i2.84965

Abstract
       Thermostable proteases are one of the pivotal enzymatic groups which play fundamental roles in biotechnologyrelated industries. The identification of bacterial thermostable enzymes through screening programs is a time and cost consuming process. So, extensive bioinformatics and experimental ...  Read More

8. Evaluation of IFN-γ and T-bet Expression Levels as Possible Molecular Markers of Schizophrenia

Roghaye Lorestani; Sohrab Boozarpour; Sakineh Alijanpour; Leila Ahangar

Volume 11, Issue 2 , Winter and Spring 2020, , Pages 82-89

http://dx.doi.org/10.22067/jcmr.v11i2.85426

Abstract
       Schizophrenia is an irritating mental disorder that affects around 1% of the world's population. The immune system contributes to the onset of the disease, particularly through production and secretion of some cytokines. In patients with schizophrenia, the balance of Th1 to Th2 ratio ...  Read More

9. Immunosuppressive Effects of Human Chorionic Gonadotropin (hCG) on Mesenchymal Stromal Cells

Sepideh sadat Hosseini; Shadi Mehrzad; Halimeh Hassanzadeh; Hamid Reza Bidkhori; Mahdi Mirahmadi; Madjid Momeni-Moghaddam; Fatemeh Sadeghifar; Moein Farshchian

Volume 11, Issue 2 , Winter and Spring 2020, , Pages 90-98

http://dx.doi.org/10.22067/jcmr.v11i2.85667

Abstract
       Mesenchymal stem/stromal cells (MSCs) as one of the most important types of adult stem cells secrete a variety of immunomodulatory cytokines. However, their immunomodulatory features strongly depend on the molecular cross-talk between cells and the surrounding microenvironment. Hence, ...  Read More

10. Vitamin E Pretreatment of Mesenchymal Stem Cells: The Interplay of Oxidative Stress and Inflammation

Shadi Mehrzad; Sepideh sadat Hosseini; Madjid Momeni-Moghaddam; Moien Farshchian; Halimeh Hassanzadeh; Mahdi Mirahmadi; Fatemeh Sadeghifar; Hamid Reza Bidkhori

Volume 11, Issue 2 , Winter and Spring 2020, , Pages 99-107

http://dx.doi.org/10.22067/jcmr.v11i2.85668

Abstract
       Oxidative stress occurs as a result of breaking down the balance between oxidants (e.g., reactive oxygen species (ROS)) and antioxidants in cells. Several studies have shown that there is a close relationship between oxidative stress and inflammation at the sites of injury. Mesenchymal ...  Read More