The use of medicinal plants in the treatment of diseases has a long history dating back to the human presence on Earth. Cancer, has always been an incurable disease, and among the various cancers, breast cancer is one of the most important causes of death in women and imposes difficult conditions on patients, although medical and surgical solutions have been proposed for this disease, but it has not been successful in the complete cure of this disease. In recent years, more studies have been done on the effects of Medicinal Plants and scientists are trying to study the control mechanisms of these plants to control the growth of cancer cells. This article focuses on two very important Genes that are of great importance in regulating the growth and proliferation behavior of normal and cancer cells. We have dealt with the effectiveness of their active ingredients. This article is an overview on P53 and MDM2 genes also P53-MDM2 signal beside Plants that exert their medicinal effect through these genes and the result of this article, which is actually a valuable list of these plant families, can be used in research that seeks to control the mentioned doses, thus the process of the effect of plants in Treatment will be seen more clearly.