Ferdowsi University of Mashhad
Volume 16 (2024)
Volume 15 (2023)
Volume 14 (2022)
Volume 13 (2021)
Volume 12 (2020)
Volume 11 (2019)
Volume 10 (2018)
Volume 9 (2017)
Volume 8 (2016)
Volume 7 (2015)
Volume 6 (2014)
Volume 5 (2013)
Volume 4 (2012)
Volume 3 (2011)
Volume 2 (2010)
Volume 1 (2009)
The effects of DNAi molecule on growth and muscle weights in male Wistar rats

Ali Javadmanesh; Amir Rashid Lamir; Mitra Riasi; مهرداد موحد نسب; نازیلا دردمه; Elnaz Karbaschian; Kasra Kayyami; Helia Khayyami

Articles in Press, Accepted Manuscript, Available Online from 04 March 2025

https://doi.org/10.22067/jcmr.2025.90056.1100

Abstract
  The growth and development of skeletal muscle tissue is largely regulated by myostatin during the tissue development in embryos. This tissue may overgrow if there is a deficiency in myostatin expression. Gene expression may be regulated in a particular way by oligonucleotide antisense molecules. It has ...  Read More

Gene Silencing Method Based on DNA

Mitra Riasi; Elnaz Karbaschian; Ali Javadmanesh

Volume 15, Issue 1 , October 2023, , Pages 7-18

https://doi.org/10.22067/jcmr.2023.84052.1077

Abstract
  DNA-based approaches can now be utilized as low-risk methods to change gene expression. It appears that this approach has the ability to partially replace RNA-based approaches for altering gene expression, which in the majority of cases leads to immunological responses in patients. When utilized as a ...  Read More

Effect of Intramuscular and Intraperitoneal Injections of conjugated MSTN-siRNA-cholesterol on Inhibition of Myostatin Gene expression

Mitra Riasi; Sina Mozaffari Jovin; Ali Javadmanesh

Volume 14, Issue 1 , October 2022, , Pages 20-27

https://doi.org/10.22067/jcmr.2022.77774.1045

Abstract
  Myostatin (MSTN) is primarily expressed in skeletal muscle tissue and acts as a negative regulator of skeletal muscle growth by inhibiting differentiation and proliferation of myoblasts. Inhibition of MSTN expression could result in muscular hypertrophy. An effective therapeutic approach based on specific ...  Read More

MicroRNA-mediated Resistance to Plant Viruses

amir ghaffar shahriari; Aminallah Tahmasebi

Volume 10, Issue 1 , September 2018, , Pages 40-46

https://doi.org/10.22067/jcmr.v10i1.70766

Abstract
  MicroRNAs (miRNAs) are 20-24 nucleotide small RNAs which are processed from nuclear-encoded transcripts. miRNAs control the expression of target transcripts by cleaving or translational inhibition of the target RNAs. Artificial microRNAs (amiRNAs) are modified endogenous miRNA precursors in which the ...  Read More