Aegle marmelos Leaf Extract is an Effective Herbal Remedy in Reducing Hyperglycemic Condition: A Pre-clinical Study

Document Type : Scientific Reports

Authors

• Afeefa Kiran ch ¹
• Muhammad Azam ²
• Arif Malik ²
• Kalsoom Fatima ²
• Saghir Ahmad Jafri ²
• Reneesh Muhammad ²

¹ UAE-University

² The University of Lahore

https://doi.org/10.22067/jcmr.v8i1.56204

Abstract

Diabetes is one of the alarming health problem in Pakistan. According to international diabetes federation (IDF),
about 7 million Pakistanis are victims of diabetes accounting a total of 3% population. Most of Pakistanis still prefer
to use herbal medicines for almost all of their health issues. Aegle marmelos (commonly known as the bael tree) is
highly reputed ayurvedic medicinal tree as it has been used in traditional medicine for centuries. In this pre-clinical
work, 32 mice were induced for diabetes via injecting alloxan intraperitoneally at a dose of 100 mg/kg body weight
and mice having 104-170 mg/dl sugar level were considered diabetic. All mice were divided into two groups, each
group with three sub-groups containing normal, control and diabetic mice. One group was given normal feed whereas
other group was given a food containing Aegle marmelos leaf extract at 300 mg/kg body weight as an effective dose
against alloxan induced hyperglycemia. The experiments lasted for 60 days and blood samples (05 ml to 1.0 ml) were
collected from coccygeal vein of rats on 1st day, 30th day and 60th day of the experiment in heparinized tubes and
blood glucose level was measured using spectrophotometer by enzymatic kit at a wavelength of 540nm. It was
observed that the Aegle marmelos leaf extract is an effective herbal remedy in reducing and maintaining the glucose
level in normal and hyperglycemic mice

Keywords

• Diabetes mellitus
• Aegle marmelos leaf
• Hyperglycemia
• Pre-clinical study

20.1001.1.20089147.2016.8.1.4.2

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