CXCR4: A Potential Chemokine Receptor for Future Regenerative Therapeutic Target

Document Type : Letters / Commentaries

Authors

• Asieh Heirani-Tabasi
• Hojjat Naderi-Meshkin

ACECR- Khorasan Razavi Branch

https://doi.org/10.22067/jcmr.v7i2.52412

Abstract

Understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics. Chemokines have been described as one of the most significant singling networks in stem cells homing and regeneration of damaged organs. CXCR4/CXCL12 has been known as a key player in this regard. Expression of CXCR4 has been observed in a number of cells such as mesenchymal stem cells, epithelial cells etc and plays crucial and unique role in the migration of cells towards a cytokine gradient and regulating stem cells trafficking as well as tissue/organ regeneration and embryogenesis.

Keywords

• Chemokine
• CXCR4
• Stem cell therapy
• Regenerative Medicine

20.1001.1.20089147.2015.7.2.3.6

References

1. Ghieh F., Jurjus R., Ibrahim A., Geagea A. G., Daouk H., El Baba B., Chams S., Matar M., Zein W. and Jurjus, A. (2015) The use of stem cells in burn wound healing: A Review. BioMed Research International 2015:9.

2. Hauser A. E., Debes G. F., Arce S., Cassese G., Hamann A., Radbruch,A. and Manz R. A. (2002) Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. The Journal of Immunology 169(3): 1277-1282.

3. Kucia M., Jankowski K., Reca R., Wysoczynski M., Bandura L., Allendorf D. J., Zhang J., Ratajczak J. and Ratajczak M. Z. (2004) CXCR4–SDF-1 signalling, locomotion, chemotaxis and adhesion. Journal of molecular histology 35(3): 233-245.

4. Li L., Wu S., Liu Z., Zhuo Z., Tan K., Xia H., Zhuo L., Deng X., Gao Y. and Xu Y. (2015a) Ultrasound-targeted microbubble destruction improves the migration and homing of Mesenchymal Stem Cells after myocardial infarction by upregulating SDF-1/CXCR4: A Pilot Study. Stem Cells International 2015:14.

5. Li Q., Tian S. F., Guo Y., Niu X., Hu B., Guo S.-c., Wang N.-s. and Wang Y. (2015b) Transplantation of induced pluripotent stem cell-derived renal stem cells improved acute kidney injury. Cell and bioscience 5(1): 1.

6. Ling K. X., Peng L., Feng Z. J., Wei C., Yan Y. W., Nan S., Qi G. C. and Wei W. Z. (2016). Stromal Derived Factor-1/CXCR4 axis involved in bone marrow mesenchymal stem cells recruitment to injured liver. Article ID 8906945, Accepted article.

7. Mao A. S. and Mooney D. J. (2015) Regenerative medicine: current therapies and future directions. Proceedings of the National Academy of Sciences 112(47): 14452-14459.

8. Naderi‐Meshkin H., Bahrami A. R., Bidkhori H. R., Mirahmadi M. and Ahmadiankia N. (2015a) Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy. Cell biology International 39(1): 23-34.

9. Naderi‐Meshkin H., Matin M. M., Heirani‐Tabasi A., Mirahmadi M., Irfan‐Maqsood M., Edalatmanesh M. A., Shahriyari M., Ahmadiankia N., Moussavi N. S. and Bidkhori H. R. (2015b) Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells: exploitation of SDF‐1/CXCR4 axis towards enhancing the efficacy of stem cells' homing. Cell Biology International Accepted article.

10. Vidaković M., Grdović N., Dinić S., Mihailović M., Uskoković A. and Jovanović J. A. (2015) The importance of the CXCL12/CXCR4 axis in therapeutic approaches to diabetes mellitus attenuation. Frontiers in immunology 6.