Document Type : Review / Mini-Review
Authors
Hakim Sabzevari University, Sabzevar, Iran
Abstract
Mesenchymal stem cells (MSCs) could differentiate into various types of tissues. These cells serve as a backup for the regeneration and repair of tissues or cells after injury. A skin wound is defined as an injury to the skin that needs to be restored. All types of cells in skin especially mesenchymal stem cells play important role in wound healing process. In particular, paracrine signaling of MSC regulates the cellular responses at the wound site leading to reduction of inflammation, stimulation of angiogenesis and induction of cell migration and proliferation. Because of these abilities, MSCs are one of the most common stem cells for cell therapy in wound healing. This review focuses on the role of MSCs on wound healing process. In addition, major phases of wound repair and challenges of cell therapy are discussed.
Keywords
Ai G., Su Y., Yan G., Wang M., Liu X., Xu H. and Cheng T. (2002) The experimental study of bone marrow mesenchymal stem cells on the repair of skin wound combined with local radiation injury. Zhonghua Yi Xue Za Zhi 82:1632-1636.
2. Balaji S., Keswani S. G. and Crombleholme T. M. (2012) The role of mesenchymal stem cells in the regenerative wound healing phenotype. Advances in Wound Care 1:159-165.
3. Behm B., Babilas P., Landthaler M. and Schreml S. (2012) Cytokines, chemokines and growth factors in wound healing. Journal of the European Academy of Dermatology and Venereology 26:812-820.
4. Bielefeld K. A., Amini-Nik S. and Alman B. A. (2013) Cutaneous wound healing: recruiting developmental pathways for regeneration. Cellular and Molecular Life Sciences 70:2059-2081.
5. Bollag W. B. and Hill W. D. (2013) CXCR4 in epidermal keratinocytes: crosstalk within the skin. Journal of Investigative Dermatology 133:2505-2508.
6. Brower J., Blumberg S., Carroll E., Pastar I., Brem H. and Chen W. (2011) Mesenchymal stem cell therapy and delivery systems in nonhealing wounds. Advances in Skin and Wound Care 24:524-532.
7. Chen M., Przyborowski M. and Berthiaume F. (2009) Stem cells for skin tissue engineering and wound healing. Critical Reviews™ in Biomedical Engineering 37.
8. Diegelmann R. F. and Evans M. C. (2004) Wound healing: an overview of acute, fibrotic and delayed healing. Frontiers in Bioscience 9:283-289.
9. Ding D. C., Shyu W.-C. and Lin S. Z. (2011) Mesenchymal stem cells. Cell Transplantation 20:5-14.
10. Eckes B., Nischt R. and Krieg T. (2010) Cell-matrix interactions in dermal repair and scarring. Fibrogenesis and Tissue Repair 3:4.
11. Falanga V., Iwamoto S., Chartier M., Yufit T., Butmarc J., Kouttab N., Shrayer D. and Carson P. (2007) Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Engineering 13:1299-1312.
12. Fathke C., Wilson L., Hutter J., Kapoor V., Smith A., Hocking A. and Isik F. (2004) Contribution of bone marrow–derived cells to skin: collagen deposition and wound repair. Stem Cells 22:812-822.
13. Guo S. and DiPietro L. A. (2010) Factors affecting wound healing. Journal of Dental Research 89:219-229.
14. Harding K., Morris H. and Patel G. (2002) Science, medicine, and the future: healing chronic wounds. BMJ: British Medical Journal 324:160.
15. Hass R. and Otte A. (2012) Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment. Cell Commun Signal 10:26.
16. Jackson W. M., Nesti L. J. and Tuan R. S. (2012a) Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem cells Translational Medicine 1:44-50.
17. Jackson W. M., Nesti L. J. and Tuan R. S. (2012b) Mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem Cell Research and Therapy 3:20.
18. Kato J., Kamiya H., Himeno T., Shibata T., Kondo M., Okawa T., Fujiya A., Fukami A., Uenishi E., Seino Y., Tsunekawa S., Hamada Y., Naruse K., Oiso Y. and Nakamura J. (2014) Mesenchymal stem cells ameliorate impaired wound healing through enhancing keratinocyte functions in diabetic foot ulcerations on the plantar skin of rats. Journal of Diabetes and its Complications 28:588-595.
19. Li H. and Fu X. (2012) Mechanisms of action of mesenchymal stem cells in cutaneous wound repair and regeneration. Cell and Tissue Research 348:371-377.
20. Li H., Fu X., Ouyang Y., Cai C., Wang J. and Sun T. (2006) Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages. Cell and Tissue Research 326:725-736.
21. Li Y., Zheng L., Xu X., Song L., Li Y., Li W., Zhang S., Zhang F. and Jin H. (2013) Mesenchymal stem cells modified with angiopoietin-1 gene promote wound healing. Stem Cell Research and Therapy 4:113.
22. Maxson S., Lopez E. A., Yoo D., Danilkovitch-Miagkova A. and Leroux M. A. (2012) Concise review: role of mesenchymal stem cells in wound repair. Stem Cells Translational Medicine 1:142-149.
23. Murphy M. B., Moncivais K. and Caplan A. I. (2013) Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Experimental and Molecular Medicine 45:e54.
24. Nuschke A. (2014) Activity of mesenchymal stem cells in therapies for chronic skin wound healing. Organogenesis 10:29-37.
25. Occleston N. L., Metcalfe A. D., Boanas A., Burgoyne N. J., Nield K., O'Kane S. and Ferguson M. W. (2010) Therapeutic improvement of scarring: mechanisms of scarless and scar-forming healing and approaches to the discovery of new treatments. Dermatology Research and Practice.
26. Olczyk P., Mencner Ł. and Komosinska-Vassev K. (2014) The role of the extracellular matrix components in cutaneous wound healing. BioMed Research International 2014.
27. Reinke J. and Sorg H. (2012) Wound repair and regeneration. European Surgical Research 49:35-43.
28. Rodero M. P. and Khosrotehrani K. (2010) Skin wound healing modulation by macrophages. International Journal of Clinical and Experimental Pathology 3:643.
29. Shi J. H., Guan H., Shi S., Cai W. X., Bai X. Z., Hu X. L., Fang X. B., Liu J. Q., Tao K. and Zhu X. X. (2013) Protection against TGF-β1-induced fibrosis effects of IL-10 on dermal fibroblasts and its potential therapeutics for the reduction of skin scarring. Archives of Dermatological Research 305:341-352.
30. Shi Y., Su J., Roberts A. I., Shou P., Rabson A. B. and Ren G. (2012) How mesenchymal stem cells interact with tissue immune responses. Trends in Immunology 33:136-143.
31. Singer A. J. and Clark R. A. (1999) Cutaneous wound healing. The New England Journal of Medicine 341:738-746.
32. Sorrell J. M. and Caplan A. I. (2010) Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Research and Therapy 1:30.
33. Teller P. and White T. K. (2011) The physiology of wound healing: injury through maturation. Perioperative Nursing Clinics 6:159-170.
34. Velnar T., Bailey T. and Smrkolj V. (2009) The wound healing process: an overview of the cellular and molecular mechanisms. The Journal of International Medical Research 37:1528-1542.
35. Volk S. W. (2010) Mesenchymal stem cells in ischemic wound healing. Wounds 1:1-3
36. Werner S. and Grose R. (2003) Regulation of wound healing by growth factors and cytokines. Physiological Reviews 83:835-870.
37. Wu Y., Chen L., Scott P. G. and Tredget E. E. (2007) Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 25:2648-2659.
38. Yolanda M. M., Maria A. V., Amaia F. G., Marcos P. B., Silvia P. L., Dolores E. and Jesús O. H. (2014) Adult Stem Cell Therapy in Chronic Wound Healing. Journal of Stem Cell Research and Therapy 4:2.
39. Young A. and McNaught C. E. (2011) The physiology of wound healing. Surgery (Oxford) 29:475-479.
40. Zou J. P., Huang S., Peng Y., Liu H. W., Cheng B., Fu X. B. and Xiang X. F. (2012) Mesenchymal Stem Cells/Multipotent Mesenchymal Stromal Cells (MSCs) Potential Role in Healing Cutaneous Chronic Wounds. The International Journal of Lower Extremity Wounds 11:244-253.
)
Send comment about this article