Therapeutic potential of Stem Cell Preconditioning for Ischemic Heart Diseases / Letter to the Editor

Mirahmadi, Mahdi; Heirani-Tabasi, Asieh; Hassanzadeh, Halimeh; Pishbin, Mandana; Bidkhori, Hamid Reza; Naderi-Meshkin, Hojjat

doi:10.22067/jcmr.v5i2.29470

Document Type : Letters / Commentaries

Authors

¹ Department of Stem Cells and Regenerative med.

² ACECR, Mashhad

https://doi.org/10.22067/jcmr.v5i2.29470

Abstract

Preconditioning (PC), is an approach to improve therapeutic potential of stem cells against ischemic environment. PC has several advantages over other therapeutic techniques as this results in increase of transplanted stem cells recruitment, retention, survival and subsequently the induction of a more supportive environment within the damaged tissue via secretion of angiogenic factors. Special attention is needed to recognize new materials, compounds, and conditions to assess the feasibility of PC for being applied in clinics to treat the ischemic diseases.

Keywords

20.1001.1.20089147.2013.5.2.9.8

References

1. Cencioni C., Melchionna R., Straino S., Romani M., Cappuzzello C., Annese V., Wu J. C., Pompilio G., Santoni A., Gaetano C., Napolitano M. and Capogrossi M. C. (2013) Ex vivo acidic preconditioning enhances bone marrow ckit+ cell therapeutic potential via increased CXCR4 expression. Eur Heart J 34:2007-2016.

2. Herrmann J. L., Wang Y., Abarbanell A. M., Weil B. R., Tan J. and Meldrum D. R. (2010) Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection. Shock 33:24-30.

3. Hung S. C., Pochampally R. R., Hsu S. C., Sanchez C., Chen S. C., Spees J. and Prockop D. J. (2007) Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS One 2:e416.

4. Kubo M., Li T. S., Kamota T., Ohshima M., Qin S. L. and Hamano K. (2009) Increased expression of CXCR4 and integrin alphaM in hypoxia-preconditioned cells contributes to improved cell retention and angiogenic potency. J Cell Physiol 220:508-514.

5. Tang Y. L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., Kishore R., Phillips M. I., Losordo D. W. and Qin G. (2009) Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res 104:1209-1216.

6. Wilschut K. J., Ling V. B. and Bernstein H. S. (2012) Concise review: stem cell therapy for muscular dystrophies. Stem Cells Transl Med 1:833-842.

7. Yu S. P., Wei Z. and Wei L. (2013) Preconditioning strategy in stem cell transplantation therapy. Transl Stroke Res 4:76

Name *

Email Address *

Affiliation *

Comments *

Security Code *

Journal of Cell and Molecular Research

Therapeutic potential of Stem Cell Preconditioning for Ischemic Heart Diseases / Letter to the Editor

References

References

Send comment about this article

Volume 5, Issue 2 - Serial Number 10
December 2013
Pages 92-93

Therapeutic potential of Stem Cell Preconditioning for Ischemic Heart Diseases / Letter to the Editor

References

References

Send comment about this article

Volume 5, Issue 2 - Serial Number 10December 2013Pages 92-93

Volume 5, Issue 2 - Serial Number 10
December 2013
Pages 92-93