TY - JOUR ID - 29986 TI - Association of TOMM40, CHAT and SORL1 Polymorphisms with the Alzheimer’s Disease in the Turkish-speaking Azeri population in Northwest of Iran JO - Journal of Cell and Molecular Research JA - JCMR LA - en SN - 2008-9147 AU - Mardokh Rohani, Nazanin AU - Khalaj-Kondari, Mohammad AU - Khodayi-Shahrak, Majid AU - Talebi, Mahnaz AU - Hoseinpur Feizi, Mohammad Ali AD - Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran AD - Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Y1 - 2020 PY - 2020 VL - 12 IS - 1 SP - 41 EP - 48 KW - polymorphisms association study KW - Alzheimer’s disease KW - English KW - SORL1 KW - CHAT KW - TOMM40 KW - Genome-wide association study DO - 10.22067/jcmr.v12i1.87325 N2 -      Recent genome-wide association studies have introduced several genetic variants which contribute to the late-onset Alzheimer's disease (LOAD). Polymorphisms of CHAT, TOMM40, and SORL1 genes have been reported to be associated with the LOAD phenotype. This study was endeavored to evaluate the association of the CHAT rs3810950, TOMM40 rs1160985 and SORL1 rs11218304 polymorphisms with the LOAD in the Turkish-speaking  Azeri population of northwest Iran. In a case-control study, we included 174 cases: 88 cases with LOAD diagnosis and 86 healthy individuals. Peripheral blood samples were collected and the genomic DNA of all participants were extracted. Genotyping was carried out by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We did not observe any significant association between the CHAT rs3810950 and SORL1 rs11218304 alleles with the LOAD. However, both the TOMM40 rs1160985 minor allele T and TT genotype showed significant negative associations with the LOAD. Hence, the TOMM40 rs1160985 polymorphism could be considered as a protective genetic factor against the LOAD in the Turkish-speaking Azeri population of northwest Iran. UR - https://jcmr.um.ac.ir/article_29986.html L1 - https://jcmr.um.ac.ir/article_29986_e744e0f15b072949cc1cf9191b24be2e.pdf ER -